menu Contact Us Dizzy Patients Health Care Providers Dizzy Culture Research Site DVD BPPV DVD Tai Chi DVD Understanding Dizziness Acknowledgements Disclaimer Quoting

ORTHOSTATIC HYPOTENSION

Timothy C. Hain, MD. Page last modified: October 12, 2014

Orthostasis means upright posture, and hypotension means low blood pressure. Thus, orthostatic hypotension consists of symptoms of dizziness, faintness or lightheadedness which appear only on standing, and which are caused by low blood pressure. Only rarely is spinning vertigo caused by orthostasis.

Symptoms that often accompany orthostatic hypotension include chest pain, trouble holding the urine, impotence, and dry skin from loss of sweating. Fainting (syncope) is covered in another page.

How common is orthostatic hypotension ?

According to Wu et al (2008), symptoms of dizziness provoked by standing ranges from 4.4% (young) to 5.8% (>=70).   Thus orthostatic dizziness is common and much more frequent than dizziness due to inner ear disturbances. 

What Causes Orthostatic Hypotension ?Blood pressure cuf

Blood pressure is maintained by a combination of several things. The heart is the central pump, and a weak or irregular heart can cause orthostatic hypotension. Conditions such as arrhythmia, heart failure, deconditioning, and pregnancy are examples where the heart may not be up to the task of providing an adequate blood pressure.

The heart pumps blood, and if there is too little blood volume (anemia, dehydration, dialysis), the pressure drops. The blood vessels in the body also can squeeze (constrict) to raise blood pressure, and if this action is paralyzed, blood pressure may fall. Numerous medications affect blood vessels including most of the medications used for blood pressure, and many of the medications used in psychiatry and for anginal heart pain. Heat, such as a hot shower or from a fever can also dilate blood vessels and cause orthostasis. The nervous system senses and responds to regulate blood pressure. If something is wrong in this control system, blood pressure may fluctuate.

Blood pressure is usually lowered (in persons with orthostasis) by upright posture, food, infection, hyperventilation, hot weather, and lifting of heavy objects. General anesthesia may be unusually dangerous due to blood pressure fluctuations (Bevan et al, 1979).

Vestibular disorders may interact with blood pressure and heart rate control. The vestibular system is one source of information about uprightness (the otoliths), there are some effects of vestibular stimulation on the heart (Radtke, 1992), and there are some patients who have a combination of autonomic and vestibular symptoms.

Neurological disorders can also be caused by orthostasis. This usually takes the form of a transient ischemic attack (TIA) precipitated by a blood pressure drop (Brozman et al, 2002).

 

Diagnosis of Orthostatic Hypotension

Syndromes with orthostatic dizziness or lightheadedness, not associated with low blood pressure include:

  1. Positional orthostatic tachycardia (POT) syndrome. Here, the pulse races on standing. See below for more information.
  2. Low CSF pressure syndrome
  3. Primary orthostatic tremor
  4. Positional vertigo (i.e. BPPV)

Syndromes with orthostatic hypotension that may be diagnosed include:

  1. Cardiogenic (heart related) orthostatic hypotension. In this instance the heart doesn't respond adequately to demands for greater pumping and blood pressure drops. Conditions such as arrhythmia, heart failure, deconditioning, and pregnancy are examples.
  2. Low blood volume (e.g. anemia, dehydration, dialysis)
  3. Medication related (usually too high doses of blood pressure medications or medications for depression)
  4. Primary adrenal insufficiency. Persons with primary adrenal insufficiency usually also have symptoms of glucocorticoid (cortisone) deficiency. The skin may be dark, serum potassium high, and there may be associated hypothyroidism, diabetes, and vitiligo (Salvatori, 2005).
  5. Neurogenic orthostatic hypotension
    1. Sensory neuropathies (diabetes, alcohol, syphilis, Holmes-Adie syndrome, carotid sinus obliteration by endarterectomy, Riley-Day syndrome)
    2. Central types:
      1. MSA - multiple system atrophy or Shy-Drager, Parkinson's, dementia with Lewy bodies. Orthostatic hypotension is nearly universal in MSA, present in about 50% of patients with dementia with Lewy bodies (Akaogi et al, 2009), and in 5-50% of patients with Parkinson's. (Thaisetthawatkul et al, 2004; Akaogi et al, 2009). However, since Parkinsonism is by far the most common disorder, there may be as many patients with orthostatic hypotension and Parkinson's disease as any of the former. Patients with MSA have intact sympathetic noradrenergic innervation.
      2. Medullary strokes or injuries (rare)
      3. Wernickes syndrome (rare, related to thiamine deficiency)
    3. Output types:
      1. Peripheral neuropathy, especially diabetes and amyloidosis
      2. Spinal cord lesions
      3. PAF - pure autonomic failure or idiopathic orthostatic hypotension. These patients have loss of cardiac sympathetic neurons, and in particular have loss of sympathetic noradrenergic innervation.
      4. Parkinson's disease (post-ganglionic sympathetic denervation). These patients also have loss of cardiac sympathetic neurons.
      5. Dopamine beta-hydroxylase deficiency (hereditary, very rare -- has very high serum dopamine, often ptosis (droopy eyes) and hyperextensible joints. Prolactin may be high)
  6. Unknown type
    1. Orthostatic intolerance in chronic fatigue syndrome (this mainly seems to be a syndrome of adolescents)
    2. Orthostatic intolerance associated with basilar migraine
    3. Delayed orthostatic hypotension. Possibly due to fatigue of autonomic system over 3-20 minutes.

The diagnosis of orthostasis is made by finding that the systolic/diastolic blood pressure drops at least 25/10 mm mercury on going from lying to standing. After measuring the supine blood pressure, it is recommended that one should have the subject stand for 2 minutes (if tolerated) before measuring the upright blood pressure (Tarazi and Fouad, 1983).

Tilt table Tilt table used at Chicago Dizziness and Hearing

An alternative and more quantitative method of determining if there is orthostatic hypotension is the tilt table test. This procedure uses equipment to record blood pressure and pulse after a 70 degree tilt using a motorized table.

Recently it has been point out that subjects who are stood for longer periods of time may exhibit progressive decline in blood pressure (Gibbons and Freeman, 2006). Delayed orthostatic hypotension (DOH ?) is defined as a greater than 20 mm Hg fall after 3 minutes or more of tilt-table or active standing. This seems to take a rather long time -- many (39%) subjects were positive only after 10 minutes of standing or tilt. A tilt (or stand) of 20 minutes was recommended by these authors for diagnosis.

The pulse (heart rate) should be checked also. The lack of a pulse response increase when the blood pressure drops implies a neurological cause.

An excessive pulse response is termed "POTS" or positional orthostatic tachycardia syndrome. POTS can be associated with considerable disability (Benrud-Larson et al, 2002). Note that pulse can increase due to anxiety and deconditioning as well as autonomic disorders and considerable caution must be used in making this diagnosis. http://cogprints.org/4802/2/raj.pdf is an external web page written for health-care providers concerning this condition.

Once an orthostatic syndrome is determined, additional tests are used to determine why the blood pressure isn't properly regulated.

Laboratory TESTS for orthostatic hyptension

TEST RATIONALE
CBC (blood count) Check for anemia -- especially important in persons who are bleeding.
EKG, other heart tests Check for weakness or irregularity of the heart
CT or MRI scan of head Exclude other nervous system disorders such as multiple system atrophy (MSA)
Autonomic testing (a battery of tests often including tests of blood pressure control and sweating). Tilt table testing, Valsalva testing, and QSART are often included. Localize lesion in nervous system
Cortisol, 6-8 AM Levels less than 3 indicate adrenal insufficiency. Levels greater than 18 are normal. Levels in the middle can be sorted out with a dynamic cortisol test (e.g. ACTH stimulation or related test)

Plasma norepinephrine (NE) (supine and standing)

Serum dopamine.

Low levels indicate post-ganglionic level lesion (vasoconstrictors like midodrine will not work in this case). Patients with orthostatic hypotension associated with Parkinsonism have low plasma levels of NE while supine, and thus should not respond to Mitodrine. Patients with MSA have normal levels. See Goldstein (2003). Patients with dopamine beta-hydroxylase deficiency have very high dopamine levels.

Glucose tolerance test, or glycosylated Hgb. Diabetes
RPR or FTA Syphilis
Urine porphyrins Porphyria
Serum electrolytes Dehydration
Serum creatinine and BUN Kidney failure when high
Gastric and small bowel motility studies Detect diabetic gastroparesis and related conditions.
Posturography Should be normal
Rectal biopsy If amyloid is suspected

Not every test is needed in every situation. More tests may be recommended based on the results of the previous tests. Tilt table tests are not needed in orthostatic hypotension, as the problem has already been idenfied, but may be indicated in persons with fainting (syncope) or simply an undiagnosed orthostatic syndrome.

Persons with orthostatic intolerance are reported to have more MRI abnormalities called periventricular white matter lesions (Kruit et al, 2013). The reason for this is unknown. We have never noticed this association ourselves in our 18,000+ patients seen over the years with dizziness.

CASE EXAMPLE:

A 57 year old man presented complaining of lightheadness on standing and a pressure sensation in the back of his neck (on standing). Other medical problems included a low thyroid. Blood pressure was 90/65 standing vs 130/80 supine (on medication). This documents a significant orthostatic hypotension. A sweat test showed about 50% anhidrosis. Norepinephrine level was about 30 units lower supine than upright. He was diagnosed as having neurogenic orthostatic hypotension. Present treatment includes Proamatine (mitodrine) 10 mg TID, salt supplements, and erythropoetin.

TREATMENT

Note that neither drug nor non-drug treatment can do as good a job as a  well working body. All of the strategies outlined in the next section are intended to alleviate symptoms, but they are unlikely to cure orthostatic hypotension.

Non-Drug Treatment for Orthostatic Hypotension

    Generally it is best to start with non-pharmacological treatment, and proceed to drug treatment only when this fails. Note that measures such as voloume expansion with increased salt and fluid, moderate exercise and tilt training are relatively safe but their effectiveness has not been demonstrated by controlled trials (Kapoor, 2003). Nevertheless, we think it is reasonable to give these things a try.

  1. Use an automatic blood pressure cuff (about $30 at Walgreens or Radio Shack). Check blood pressure and pulse daily, preferably standing and lying flat, and record it. Also check blood pressure when you have symptoms.
  2. If possible, eliminate medications that lower blood pressure (usually blood-pressure or heart medications). Check with your doctor first, however, to be sure that this is safe. Sometimes it is helpful to take the blood pressure medications in the evening, as well as to use longer acting ones rather than ones that act quickly.
  3. Take in extra amounts of salt - about 10 gm/day total. Another way to get extra salt is to use salt containing beverages (e.g. "gatorade"). If you start to have trouble breathing or get excessive swelling at the ankles, you may have to use less than 10 gm. Similarly, be careful not to overdo it and end up with hypertension.
  4. Wear Jobst stockings (tight custom made leotard like garment -- worn by both men and women). These are often not well tolerated, especially in the summer.
  5. Sleep with head of bed elevated about 15-20 degrees (4-6 inches). This maneuver increases blood volume and, after a few days, is helpful.  It is also helpful in that it may reduce supine hypertension( sometimes blood pressure is too high lying flat, and too low standing up). Try to be up during the day, not lying in bed. Reconditioning may be helpful for persons who have been on bed rest for long periods of time.
  6. Eat frequent small meals (because eating lowers blood pressure). Avoid sudden standing after eating.
  7. Avoid straining at stool (because this may lower the blood pressure)
  8. Avoid hot showers or excessive heat. Use air conditioners.
  9. Get up gradually in the morning. Take 5 minutes to get up and use support. Perform isometric exercises before moving about.
  10. Water injestion - -drinking 16 oz of water over 5 minutes can prevent a fainting spell (Lu et al, 2003).. This should not be done very often as it could lead to water intoxication.
  11. Orthostatic training. Under the supervision of a physical therapist, gradually increased upright stance. Also use physical countermeasures (see page on tilt training). The literature suggests that this is very effective.

Tilt-training, a series of prescribed upright posture exercises may be helpful in vasovagal faints as well as orthostatic faints. Tilt training also includes some effective physical countermeasures such as leg-crossing with lower body tensing, squating, and arm-tensing (Benditt and Nguyen, 2009)

Physical conditioning may also be useful for patients with orthostatic intolderance as deconditioning is present in almost all patients (Parsaik et al, 2014).

DRUG TREATMENT for Orthostatic Hypotension

Certain medications may be helpful, usually as a combination. Most useful drugs are Florinef (fludrocortisone) and Midodrine.

OTHER TREATMENTS:

Atrial pacing can be considered when the heart rate is very low. Pacing has been reported not helpful in treatment of recurrent vasovagal syncope by Connolly (2003) but is reported helpful by others (Wohrle and Kochs, 2003). We think it is best to be conservative and skeptical in situations where implantable devices are studied due to the impossibilty of obtaining placebo controls. Pacemakers may be effective in carotid sinus syndrome (a cause of syncope, not orthostatic hypotension).

3,4 Dl-threo-dihydroxyphenylserine (DOPS), an artificial amino-acid, may be helpful in certain situations (Freeman, 1996) including dopamine beta-hydroxylase deficiency and post-prandial hypotension from various etiologies. L-DOPS is a precurser of norepinephrine and epinephrine. L-DOPs has also been used on an investigational basis (Gibbons et al) in persons refractory to other drugs. It is also available in asian countries, and is sold under the brand name of Droxidopa. L-DOPS can be combined with a peripheral dopamine decarboxylase inhibitor such as carbidopa (Lodosyn) to increase levels of the drug within the CNS. L-DOPS, in doses up to 600 mg TID, is presently undergoing research trials to determine if it is effective. It is difficult for us to see how this medication differs substantially from other adrenergic agonists such as mitodrine or ephedrine.

REFERENCES:

Related Web pages

Relevant Books

n
Copyright October 12, 2014 , Timothy C. Hain, M.D. All rights reserved. Last saved on October 12, 2014