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Osmophobia in Migraine

Timothy C. Hain, MD, Chicago IL. Page last modified: July 7, 2016

See also: sensory sensitivity in migraine light sensitivity pressure sensitivity sound sensitivity

Osmophobia means "abnormal sensitivity to smell". It is an uncommon symptom with few causes. As is the case with sound and light sensitivity, there is an attempt to distinguish between having a lower threshold, and having greater discomfort.

Sense Threshold Discomfort Measure
Light Light sensitivity Photophobia  
Sound Hyperacusis Phonophobia LDL
Smell Smell sensitivity Osmophobia  
Weather Barosensitivity ? Barophobia ?  
Pain Allodynia    
Motion sensitivity kinesiophobia Motion sickness Various questionnaires

The technology of measurement of these things is best worked out for sound, where assessment of "LDL" or loudness discomfort levels are routine when fitting hearing aids.

One would think that for all of these situations, one should "adjust" the discomfort level for the threshold -- or in other words, attempt to differentiate between the input to the brain and the response to the brain. For hearing, this can be done by subtracting the pure tone threshold from the LDL. This simple concept does not seem to have penetrated into the literature about other senses.

For smell in particular, thresholds vary with nasal congestion and age. Older people can't smell as well as younger people, and persons with clogged noses can't smell much of anything.

Another consideration is that as is the case with light, sound, and other senses, during a migraine, smell may be more bothersome to migraine patients.

Increased sensitivity to smell as well as other irritants may be a personality characteristic -- Bell et al (1994) suggested that "cacosmia" -- sensitivity to environmental chemical odors was associated with high ratings for stress in the first 4 decades of life, as well as increased prevalence of physician-diagnosed nasal allergies, breast cysts, hypothyroidism, sinusitis, food sensitivities, irritable bowel, and migraine headache. We suspect there is something to the idea that there are individuals who have a sensitive personality style.

Demarquay et al (2006) used the term "hedonicity" for the pleasentness of smells, and reported that patients with olfactory hypersensitivity judged odors less pleasant, but of equal intencity. Saisu et al (2011) reported how "offensive" odors were to migraine patients, and noted that perfume, rose and Japanese cypress odors were more "offensive to migraine patients" than controls. One would naturally wonder if patients with migraine might be conditioned to dislike strong odors, because of the association with pain. In other words, perhaps this is a learned response.

Finally, some patients with migraine, as is the case as with light, may have an "olfactory aura". (Diamond et al, 1985; Coleman et al, 2011; Mainardi et al, 2016).

Triggering of migraine with smells

Similarly to loud noise, motion, or strong light, strong smells have been reported to cause migraines.

Blau and Solomon (1985) reported that odors, pleasant or otherwise, could precipitate migraine in 11 out of 50 patients.

Smell as a diagnostic criteria for migraine

The general consensus is that smell is very specific but insensitive. Here we are talking about the offensiveness of odors, not whether or not they can be detected.

Spiering's et al (2001) reported that weather, smell smoke and light were precipitating factors that differentiated migraine from tension headache. Silva-Neto et al (2014) also suggested that osmophobia "may be a specific marker to differentiate migraine from tension-type headache". As both migraine and tension are artificial constructs based on meeting entirely subjective criteria, we are dubious that there is much significance to this observation other than the question set answer affirmatively by migraine patients seems to correlate with osmophobia as well.

Kelman (2004) reported that nearly half of 724 migraine patients reported perfume or odor triggers for migraines. This seems a bit high. Kelman reported again in 2004 that "Osmophobia and taste abnormalities were demonstrated to be very specific in diagnosing migraine IHS 1.1-1.6, but very insensitive." This seems more reasonable.

Zanchin et al (2005) again concluded that osmophobia is a very specific marker for migraine, separating it from other primary headaches and tension headaches.

Corletto et al (2008) again concluded that osmophobia is specific but insensitive.

De Carlo et al (2012) reported that osmophobia is "one of the major predictors for the development of migraine".

Wang et al (2012) suggest that osmophobia might be a preferable diagnostic criteria in asian migraineurs, among whom photophobia was less common.

 

Intensity of smell perception in migraine subjects.

Drummond paper

Figure 2 from Snyder and Drummond (1997).

Snyder and Drummond (1997) compared 20 patients with migraine, mainly women, with 21 patients with fewer than 8 headaches per year. They found that patients with migraine or migraine with aura had slightly lower thresholds to vanillin than controls. The migraine patients did not find acetone more unpleasant than controls.

Hirsch (1992) reported that 18% of patients were low or unable to smell Pyridine. This is somewhat opposite to Synder and Drummond, but perhaps there is something special about Pyridine. Somewhat similarly, Marmura et al (2014) reported that about 25% of their 42 migraine attack subjects reported a drop in their sense of smell during attacks. Again, Whiting et al (2015) reported that migraine subjects were slieghtly less sensitive to the UPSIT test on both migraine and non-migraine days.

It would seem from these data that tsmell intensity ratings are unlikely to be useful.

References:

 

Copyright August 3, 2016 , Timothy C. Hain, M.D. All rights reserved. Last saved on August 3, 2016